URTIs eg, tonsillitis, sinusitis, otitis media. Lower resp tract infections eg, acute & chronic bronchitis, lobar & bronchopneumonia. GUT infections eg, urethritis, cystitis, pyelonephritis. Skin & soft tissue infections eg, abscesses, cellulitis, boils. Bone & joint infections eg, osteomyelitis. Other infections eg, abortion sepsis, puerperal sepsis, intra-abdominal sepsis, septicemia, peritonitis, post-op infections. Prophylaxis against infection which may be associated w/ major surgical procedures eg, GI, pelvic, cardiac, renal, head & neck, joint & biliary tract surgery.
Dosage/Direction for Use
InfectionsAdult & childn >12 yr 1.2 g inj 8 hrly. Childn 3 mth-12 yr 30 mg/kg 8 hrly. In more serious infections, increase frequency to 6 hrly. Childn 0-3 mth 30 mg/kg 8 hrly. In more serious infections, increase frequency to 8 hrly. Surgical prophylaxis 1.2 g inj given after the induction of anesth. Operations where there is a high risk of infections eg, colorectal surgery, may require 3-4 times daily.
Contraindications
Hypersensitivity. Neonate whose mother is hypersensitive to penicillin or its derivatives; patient w/ cholestasic jaundice history (hepatic impairment) that is related to penicillin or co-amoxiclav usage.
Special Precautions
Hypersensitivity to penicillin. Liver impairment; maintain liver function monitoring; renal impairment. Prolonged use may result in overgrowth of nonsusceptible organisms. In high doses administration, fluid intake & urine excretion should be ensure in excessive amount, to reduce the possibility of crystalluria. Patients using catheter should be in close monitoring. Pregnancy & lactation.
Blood products or proteinaceous fluids eg, protein hydrolysates or w/ IV lipid. Aminoglycoside, should not be mixed in the syringe or IV fluid container because loss of activity of the aminoglycoside can occur. OCs. May prolong bleeding time & prothrombin time in patients w/ anticoagulant therapy.
J01CR02 - amoxicillin and beta-lactamase inhibitor ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.
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